ParkinsonCanadaV1, Main, Exploration, bibRecord, 002D43

Clustering of Parkinson disease: Shared cause or coincidence?

Identifieur interne : 002D43 ( Main/Exploration ); précédent : 002D42; suivant : 002D44

Clustering of Parkinson disease: Shared cause or coincidence?

Auteurs : Ajit Kumar [Canada] ; Susan M. Calne [Canada] ; Michael Schulzer [Canada] ; Edwin Mak [Canada] ; Zbigniew Wszolek [États-Unis] ; Chris Van Netten [Canada] ; Joseph K. C. Tsui [Canada] ; A. Jon Stoessl [Canada] ; Donald B. Calne [Canada]

Source :

Archives of neurology : (Chicago) [ 0003-9942 ] ; 2004.

RBID : Pascal:04-0436282

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Aged, Cluster Analysis, Environment, Female, Humans, Male, Middle Aged, Mutation, Nervous system diseases, Parkinson Disease (epidemiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson disease.
MESH :
- epidemiology : Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Adult, Aged, Cluster Analysis, Environment, Female, Humans, Male, Middle Aged, Mutation.

Abstract

Background: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. Objective: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. Design and Patients: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the α-synuclein, parkin, tau genes, and spinocerebellar ataxia genes (SCA2 and SCA3) were negative. Results: The probabilities of random occurrence (P values) in the 3 clusters were P=7.9×10^-7 for cluster 1, P=2.6 × 10^-7for cluster 2, and P=1.5 × 10^-7 for cluster 3. Conclusions: Our findings indicate an important role for environmental causation in Parkinson disease. A possible role exists for environmental factors such as viral infection and toxins in the light of current evidence.

Affiliations:

Canada, États-Unis

Le document en format XML

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<term>Aged</term>
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<term>Environment</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Nervous system diseases</term>
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<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cluster Analysis</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Background: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. Objective: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. Design and Patients: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the α-synuclein, parkin, tau genes, and spinocerebellar ataxia genes (SCA2 and SCA3) were negative. Results: The probabilities of random occurrence (P values) in the 3 clusters were P=7.9×10<sup>-7</sup>
 for cluster 1, P=2.6 × 10<sup>-7</sup>
for cluster 2, and P=1.5 × 10<sup>-7</sup>
 for cluster 3. Conclusions: Our findings indicate an important role for environmental causation in Parkinson disease. A possible role exists for environmental factors such as viral infection and toxins in the light of current evidence.</div>
</front>
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La maladie de Parkinson au Canada (serveur d'exploration)

Clustering of Parkinson disease: Shared cause or coincidence?

Clustering of Parkinson disease: Shared cause or coincidence?

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.